Advantages of the Tire Type Mobile Crushing Plant Essay Example for Free

Advantages of the Tire Type Mobile Crushing Plant Essay The tire type mobile crushing plant is with flexible combination and high adaptability; according to different process requirements, the flow can either be in the mode of â€Å"crushing first and then screening†, or in the mode of â€Å"first screening, and then crushing†. The crushing plant can be combined into either two screening systems, namely, coarse crushing system and fine crushing system, or three screening systems, namely coarse, medium and fine system. So, it has a high flexibility and can meet different customers’ demands. According to the customers’ application demands, the tire type mobile crushing plant is divided into standard type and Closed-Circuit type, as well as multi-combination type according to the expanded demands of high-end users. Hongxing Machinery thinks that enhancing the comprehensive utilization of the construction waste is the important approach of economizing land and resources, and in the meantime is an important work of cleansing the city environment, is important measure of the development of recycling economy and the construction of environment friendly and resource-saving society and is the inevitable requirement for the implementation of the scientific development outlook and the realization of sustainable development and environment protection. Henan Hongxing Mining Machinery Co. , Ltd launched a new product into the market which is mobile crushing station, which has become the first and largest construction waste disposal company in the Middle China. This machine has a 4 million tons/year of processing power. The renewable aggregate which firstly dealt with by this equipment and then produced by the sand maker can become various kinds of environmentally-friendly building materials such as hollow bricks, plant grass brick, square brick, permeable brick, floods and tooth tile, etc. It solves the problem of environmental purification and sustainable use, and making full use of this machine greatly reduces the fees produced in the transportation of the construction waste, reduces the pollution of environment and the purification artificial work and life of the urban environment. This equipment is able to make multilevel crushing with the help of crushing and screening machines like impact crusher and divides it into three kinds of renewable aggregate, for this reason, it is widely applied in the building material industry and opens up a new road of energy save and environmental protection.

An Analysis On Dominos Pizza Marketing Essay

An Analysis On Dominos Pizza Marketing Essay This report focuses on the marketing activities by Pizza Hut, Dominos and Papa Johns as part of the fast food market. The report has looked at culturally diverse markets being China, India, USA and Mexico. Looking at the various cultures through an etic approach the report aim to convey the different levels of standardization and adaptation that companies have tried to establish in international markets. Through the marketing activities that have been carried out by each company respectively, this report forms a connection with cultural theories by theorists like Hofstede and Hall with the aim to establish which company is standardized or either adapted. In respect to the advertising activities, each company has been alert to meet local cultures in different countries. Eliciting responses that incorporate culture specific aspects like the Guan-xi and the Compadre in high context cultures and catering to the needs of low context cultures with increasing factual analysis in countries like USA, the selected companies have shown their high levels of local responsiveness. Through the report it is evident that have targeted their advertising to their standardized business model focusing on in house dining or a delivery system or even a standardized concept of the quality of products. Sales promotions done by these companies have brought to light the increasing elements of standardization as consumers are becoming increasingly technologically advanced in this mobile generation. Dominos has standardized its technological efforts gaining a competitive advantage giving customers the ability to see the exact location of their pizza during manufacture, customization of the pizza, online delivery etc. these companies have also been quick to gain public attention through local social media portals. Pricing affecting the level of standardization and adaptation, as this reports reflects. Affected by differing economic levels in different countries along with the stage in the product life cycle reached affecting the degree of standardization. Customer preferences and their disposable incomes also play a significant role on pricing and through the use of companies like Dominos, Pizza Hut and Papa Johns this report aims to communicate these links. With respect to the brands of the three companies the report sheds light on the different choices made by the company to maintain brand coherence and establish a meaningful relationship with their customers. With local adaptations the findings suggest branding develops a personality over time and when changed can result in negative attention. Branding when adapted correctly increases resonance the highest level in the customer based brand equity pyramid. This report also brings to mind the cultural aspects that link to websites being the initial contact point with customers and thus must be very culturally sensitive. Through the analysis it is evident that companies have adapted their websites in terms of subtle characteristics such as colour, gestures displayed, images, information provision as these affect the degree of standardization. Through this report the findings suggest that although standardization includes the benefits of economies of scale, generation of a better brand image in the global market and easier operations by the company there is an increasing need for adaptation as cultures although can be compared are greatly distinct and have to be acknowledged for a company to succeed in a host country. Introduction: The report based on the fast food market focuses on pizza making brands Dominos, Pizza Hut and Papa Johns. This report concentrates on the activities carried out by these brands across the globe in countries such as the United States of America, India, Mexico and China analyzing how cultural differences affect each brand (Fig -1). Through the analysis of the level of standardization and adaptation adopted by these brands across diverse cultures the report sheds light on the chosen companies activities: Websites, Sales Promotion, Advertising, Branding and Pricing. In the business environment is it integral to understand the differences in cultures, attitudes, environments etc. that requires firms to view their companies through a range of indices. Standardization gives companies an increasing advantage in terms of economies of scale along with common brand images as consumers have become increasingly mobile (Levitt, 1983; Craig, 1986, Yip, Loewe and Yoshino, 1988 as cited by Theodosiou and Leonidou, 2003). Dominos, Pizza Hut and Papa Johns have tried to internalize these benefits although as contended by Terpstra and Sarathy in 2000 (Theodosiou and Leonidou, 2003) these firms are affected by factors like culture, purchasing power and consumer needs therefore encouraging adaptation. This report aims to analyze marketing activities in different economically developed markets such as China and India belonging to the BRIC nations, Mexico a developing country and USA a developed nation. These markets give insights into differing price sensitivities affecting the products being sold respectively. Marketing Activities Analysis Advertising Pizza hut, Dominos and Papa Johns generally make use of Television commercials to advertise their products around the world. They use TV commercials as it enables them to reach a large target audience to deliver their marketing communications. This pull strategy fits in with the companys budgets and is adapted to meet the local requirements of the countries in which they are viewed in thereby promoting sales. Dominos Table 1 Country Tagline Language of advertisements Snap Shot of the Tagline India USA China Mexico Yeh hai rishton ka time (This is the Time for Relationships) Oh Yes We Did! 30 minutes fast heat delivery. Hindi English Chinese Surce: (Dominos.co.in, 2012) Analysis on Dominos Pizza Dominos Pizza has differentiated itself by advertising and positioning itself differently in different countries. Having altered their advertisements to local languages Dominos is able to communicate in a better way to their customers. Though their standardized pull advertising strategies (Ghauri and Cateora, 2010) the company has generated increased amounts of interest in the consumers and Dominos continues to achieve this through their adapted sales promotions. Dominos have also adopted an identical ad in two of our chosen countries being USA and Mexico, wherein the commercial speaks about the product changes that have been made in order to improve the quality of the pizzas. This global prototype ad has been adapted locally being locally responsive (Ghauri and Cateora, 2010). Dominos has also adopted a standardised pattern throughout its operations in different countries although there are elements of adaptations that can be seen through their differing taglines etc. Dominos has al so been alert to meet cultural imperatives in countries like Mexico and China in terms of compadre and guan-xi as the commercials focus on relationships and friendships being established with the brand, this tends to positively effect sales (Ghauri and Cateora, 2010). Another interesting finding has been the fact that Dominos throughout its operations in both international and home markets have focused their attention to their fundamental delivery model as they gain a competitive advantage from delivery in the pizza business. Pizza Hut Table 2 Tagline Language of Advertisements Snap Shot of the Taglines India USA China Mexico Pizzas and Much More Make it great Pizza and More Hindi English Chinese Analysis on Pizza Hut Pizza hut has been marketed in a way to meet the requirements and the likings of different countries. Throughout the advertisements that are set out by Pizza Hut it is evident that their emphasis has been on their in-house dining experience. In most commercials there are snapshots of the waiters, the ambiance, the furniture etc. This standardisation with local adaptations in terms of their different products that cater to local consumer taste preferences displays the companys emphasis on their in house dining services instead of their delivery. Mexico on the other hand portrays commercials incorporating different settings on a ship, or at a rock concert and even in consumers homes. This can be linked to the fact that Pizza Hut does not cater to the online market but caters to customers over the phone (Pizzahut.com.mx, 2008) (Fig 2.10). This can be seen as a decision to cater to the economic condition of the market, as Pizza Hut has adapted their delivery channel (Theodosiou and Kats ikeas, 2001). Fig 2.10 Pizza Hut ads in Mexico Papa Johns Pizza Table 3 Tagline Language of Advertisements Snapshots of Taglines India USA China Mexico Better Ingredients Better Pizza Better Ingredients Better Pizza Better Ingredients Better Pizza Better Ingredients Better Pizza Hindi English Chinese Spanish Source: (YouTube, 2010) Analysis on Papa Johns Papa Johns uses a standardized tagline for Indian, Mexican, USA and Chinese marekts. Papa Johns have effectively used their CEO and produced high performing ads. Consumers have perceived these ads to be authentic and genuine (Kelso, 2012) giving Papa Johns consumers an image wherein the company cares and is about real people creating a personal connect with the consumer. Overall Analysis: As advertising is a basic necessity in the marketing mix of an international brand, the chosen companies Dominos, Pizza Hut and Papa Johns have translated the needs and wants of their local consumers. Through the use of adapted symbols these companies have also aimed to meet the cultural needs of local consumers. We have also seen that the companies have adapted their languages in different countries, which is intrinsically linked to different cultures (Ghauri and Cateora, 2010). Dominos and Pizza Hut have equalized their effects of both standardisation and adaptation, which is evident in their advertisements and their messages to respond locally. Papa Johns on the other hand have adopted pattern advertising, which can be linked to the concept of thinking globally, acting locally (Ghauri and Cateora, 2010), as the brand has a common mission to provide Better Ingredients Better Pizza, but still has adapted its advertising strategies in different markets. Through this example it is evi dent that B2C advertising is greatly heterogonous as the transferring success across different countries is increasingly difficult and therefore must be adapted. WEBSITES PIZZA HUT INDIA PIZZA HUT CHINA Source: (Pizzahut.com.cn, 2012) PIZZA HUT USA Fig-3.10 Food allergies and sensitivities Fig-3.12 Book it page PIZZA HUT MEXICO Fig-3.16 Nutrition ANALYSIS Pizza Hut USA has a red background which in most western cultures signifies Christmas as it is widely celebrated across USA and Mexico uses brown which means practical, down-to-earth and comfortable (Empower-yourself-with-color-psychology.com, 2009) this encourages customers to make purchases and are attracted to the websites. Pizza Hut India website also has a red background for its homepage and its delivery page. Red in India symbolizes Indian weddings and the Indian bride (Empower-yourself-with-color-psychology.com, 2009) thereby attracting the Indian customer. China has a light yellow background which depicts royalty and honour in Chinese culture reflecting the standard of service provided by the company in China, being compared to a 5* experience. (Empower-yourself-with-color-psychology.com, 2009). DOMINOS PIZZA INDIA Source: (Dominos.co.in, 2012) DOMINOS PIZZA CHINA Source: (Dominos.com.cn, 2013) DOMINOS PIZZA USA Fig-3.27 Tracker Page DOMINOS PIZZA MEXICO ANALYSIS Dominos has standardized layouts of its websites across the globe with white as its background colour. White symbolizes weddings and brides in the USA, and is a symbol of peace and purity in Mexico, India and China (Geert-hofstede.com, 2013) thereby motivating a purchase as customers feel relaxed when on the page. However, adaptations have been made to fit the different markets and bridge the cultural gaps (Ghauri and Cateora, 2010) PAPA JOHNS INDIA PAPA JOHNS CHINA PAPA JOHNS USA Fig-3.44 Investors Page PAPA JOHNS MEXICO Fig-3.45 Homepage ANALYSIS Overall, a certain level of standardization is seen in Papa Johns websites across countries. The websites in all four countries follow the colours of the logo. Green symbolizes new beginnings and white is sign of peace and purity in all four cultures (Empower-yourself-with-color-psychology.com, 2009), which subtly encourages purchases. There is also a degree of adaptation displayed in the websites. Sales promotions, advertisements and languages are adapted in context to the cultural values of each country. OVERALL ANALYSIS Dominos Pizza has a comparatively higher degree of standardization in its website layout in all four countries as compared to the websites of Pizza Hut and Papa Johns Pizza. Dominos website background colour is mainly white in all four countries unlike Pizza Hut and Papa Johns which have adapted their background colours in accordance to the culture of the respective countries. Pizza Hut India has adapted its website layout according to the countrys high-context culture. It shows an employee using various non-verbal communication techniques to promote its products, which is not shown in the websites of the other three countries. However, Pizza Hut does not provide the option of creating your own pizza and pasta, which is offered, by Dominos and Papa Johns. Finally, Papa Johns aims to make a connection with its customers by displaying pictures of its founder and brand ambassador, John Smith on the homepages of all four countries. Therefore, although there is certain degree of standardi zation in the websites of Pizza Hut, Papa Johns and Dominos, there are also certain adaptations that have been made in consideration of the cultural differences in each country. Websites being increasingly important in creating a link with the customers, as it is a direct portal between the brand and the customer, they must be increasingly adapted to accommodate cultural differences. Websites have also reduced the barriers between customers and the company as it has become increasingly accessible over the Internet in multiple countries. SALES PROMOTION Dominos India Dominos Mexico Fig 4.8 ONLINE-ORDER DEALS Analysis: Dominos has standardised its sales promotion in three of the four countries USA, Mexico and India through Facebook uploading coupons, unveiling new items, added to their menu. These promotional items being adapted from their domestic operations are culturally accepted in the countries in which they feature and hence have increased sales and adoption rates in short periods of time (can sales promotions go global). Dominos in both USA and India have used an adaptive approach for their sales promotion through Mobile Applications. China and Mexico both do not have a Mobile Application option for their customers. In USA the app., shows the Pizza Tracker option in which people can track their order progress status (Dominos, 2012). In the Indian app., they have not adopted such style of service to the customers and kept it simple to place an order. Dominos mobile applications technology gives the company a cutting edge advantage as 80% of smartphones have ordering apps (Dominosbiz.com, 20 08). In countries like China and India, Dominos has introduced its 30 Minutes or Free sales promotion. This effective sales promotion attracts new customers as a way of increasing sales in a short span of time. Furthermore, both Dominos USA and India have used the Electronic and Plastic cards option for their customers, whereby, they can send their loved ones greeting cards or vouchers by mail or post for usage in Dominos. Mexico USA have used another system of combining few options to offer to customers who come in a group of 2 or 3 to 5. They can thereby select a type of pre-fixed menu which differentiates with India and China Dominos. Papa Johns India Papa Johns China Papa Johns Mexico Papa Johns USA Analysis: Papa Johns Pizza does not have a mobile application (standardised for the global market) for its sales market in any of the countries, they just keep it normal by online or phone orders. Taylor Swift being one of the most top and famous singers of USA came to an agreement with Papa Johns Pizza of her album RED to be sold along with a Large Pizza as a promotion. Papa Johns, USA started Papa Rewards, a Gift Shop and an E-Gift card facility in only one country which elicits brand awareness through these sales promotions thereby increasing sales. American Football being one of the most popular sport of USA (Usatourist.com, 1998), Papa Johns came up with a two million free pizza scheme in collaboration with NFL targeting the local sport-freak customers (adaptive). Pizza Hut India Pizza Hut USA Pizza Hut Mexico Fig 4.27 Online Deals Targeted Football Followers Pizza Hut China Analysis: Pizza Hut has incorporated the same pre-fixed menus in all countries chosen (India, Mexico, China USA). They have adapted these to meet social and cultural norms. In India, Mexico and China they cater to a smaller group of people starting with 2 individuals, whereas in USA they cater to a larger group of people starting with 8. This aims to target groups of customers. Due to the recession period, the lower-priced chains gained sales and the bigger chains lost theirs sales. To gain some of its lost market share, Pizza Hut launched a $ 10 promotion by which customers could get any pizza, any crust and any topping for $ 10 thereby stimulating an immediate increase in their sales (Franchisedirect.com, 2010). Mexico and USA have used a similar approach towards their customers by setting a contest of winning a double trip to Football finals and Gamer Vacation of Maxim Magazine Party Spot respectively since Football is very well known and famous in both the countries. The Gamer Vacation contest is held mainly to attract the teenage category customers and influencing them to buy more beverages so that they can build the game pieces. Gift cards available in USA and India have been adapted to meet the local market taste through the personalisation of messages. In Mexico China they do not have this type of feature. Pizza Huts mobile application enables customers to place orders online, which has been adapted only in their two big markets USA China. Pizza Hut China has adapted its Childrens Party theme with a South African theme and a London theme as the children are very fascinated by the foreign countries thus getting attracted by such birthday parties (Pizzahut.com.cn, 2012) Overall Analysis: Sales Promotion/marketing activities are incorporated to attract customers and to promote their products (Ghauri and Cateora, 2010). Pizza companies use value meals and promotions/rebates to attract budget minded customers (Franchisedirect.com, 2010). These demonstrations do significantly well in less economically developed countries where prices are out of the reach of customers. (Can sales promotions go global) Dominos quoted that technology is playing an important role in their daily sales as it is convenient for users and customers can use it in their own time as they are more relaxed in ordering over the app. It added millions in revenue for Dominos just via the mobile app. Pizza Hut also quoted that it boosted its sales by $ 1 million in a period of five months from July to November 2009 (the initial period of launch) (Franchisedirect.com, 2010). Papa Johns has not yet adopted any kind of mobile application business for their customers. Facebook and Twitter are becoming a vital medium of sales promotion for the chain of stores. It has been quoted that 85% of the Pizza-chain sales are through promotions and discounts acquired through these social media websites according to the Citigroup Global Markets (Franchisedirect.com, 2010). The previous version of sales promotion was not effective enough since it could not target any specific group. Furthermore, these social media portals are more cost effective methods of marketing and promoting the products (Baker, 2012) India, USA and Mexico have aggressively marketed their products via Facebook and Twitter nowadays while China is still lacking behind this procedure due to government regulations which prevent foreign social media and micro-blogging websites. In order to meet the growing need for social media and microblogging in China the government has introduced an inter-country social media and micro-blogging websites such as Weibo.com, e.t.qq.com, renren.com that incorp orates different sales promotion as mentioned below (Table 1). They restrict these websites to avoid any sensitive issues to be discussed publically and become a revolt against the government officials (Branigan, 2009). Table 1 Websites: Facebook Twitter weibo e.t.qq renren Social Media Micro-blogging Micro-blogging Micro-blogging Social Media Dominos India, USA and Mexico India, USA and Mexico Pizza Hut India, USA and Mexico USA and Mexico China China China Papa Johns Pizza India, USA and Mexico India, USA and Mexico China With the introduction of a variety of sales promotions companies are able to significantly increase short-term sales encourage repurchase and increase buyer switching between brands. (can sales promos go iglobal) Pricing: Dominos Pizza: Dominos USA: General Analysis: At Dominos, by adopting a standardized strategy to their supply chain and dough manufacturing processes Dominos has been able to control price escalations (Fig 5.3) . Their One Brand One System policy (Dominosbiz.com, 1983) incorporates firms using the same core products and proven suppliers maintaining consistency and quality standards across different countries. This standardization has also given rise to increased buyer power from the company giving them a competitive edge in terms of prices of equipment and non-food items. Dominos has also lowered their distribution costs by implementing a shorter internalized distribution channel. Dominos has a set of Master Franchisers who further contract Sub Franchisers adapting itself to meet cultural differences affecting the deeply rooted channels giving increased localized information. (Fig 5.4) Fig 5.4 Master Franchisers and Sub Franchisers Dominos have also standardized their business model that solely caters to delivery and carry out pizza (Doctoroff, 2012). In developing countries although Dominos has incorporated tables in their outlets. Its purpose has not been to change its business model towards in-house dining but in fact to cater to local market needs. This does not affect prices, as high investments in the delivery of a service do not have to be incurred by the company. Papa Johns Pizza: Papa Johns China General Analysis: Papa Johns is aware of the drawbacks of competitor based pricing and hence have focused their pricing strategy by meeting a premium price point (Morrison, 2012). Papa Johns claims that their products are aimed at meeting the needs of those who are looking to purchase products providing them with value and better quality as their tag line suggests- Better Ingredients. Better Pizza. (Papajohns, 2013). This standardized approach that has been adopted has been able to maintain Papa Johns global coordination. Their prices have been set higher than competitors prices communicating the perceived value of the products although they have not been placed at a level where they do not generate sales as Papa Johns is part of the big four pizza franchisers (Franchisehelp.com, 2013). Papa Johns have influenced their prices by standardizing their entry modes into international countries through a franchising model as their products are perishable and need to be located near the consumer and consump tion of the product. Pizza Hut: Pizza Hut India: Pizza Hut Mexico: Source: Nytimes.com, 2010 General Analysis: Pizza Hut has standardized their business model and aims to meet high standards through their increasingly important service scape. Their restaurants give consumers a 5 star feel, which has been replicated throughout their operations in both domestic and international markets. This increasingly high standard of their service scape has increased their costs, as they need to meet a range of standards in terms of staff, furniture, cutlery etc. These significantly increase costs and are reflected through in the pricing strategies. By adapting their pricing strategies at Pizza Hut they have been able to gain a competitive advantage meeting the growing diversity in the food market. Pizza hut also sources their materials and equipment locally which helps manage price escalation. Branding Papa Johns Analysis: Brands today have an increasingly important role as they are termed to be the most valuable assets companies have (Ghauri and Cateora, 2010 p.286). Dominos and Pizza Hut have adapted a their brand over time to match a dynamic market. This can be seen through their change in logo and packaging respectively. Pizza Hut received a negative response from their consumers as the brand had formed a strong relationship with them. Dominos has benefitted from their change and they have adopted this change throughout their operations in USA. Papa Johns a having a transferrable logo has been able to standardize its logo throughout their operations (USA, India, Mexico and China) providing meaningful associations as the brand aims to provide customers with better quality products. Looking at countries like India, China, Mexico and USA companies like Papa Johns, Dominos and Pizza Hut have aimed to further strengthen their brand image with affiliations with other brands like Coca- Cola and Pepsi, which shows (Table 1) the different beverages used by the pizza companies. Conclusion: Despite the profound benefits brought by standardization this report lays emphasis on the fact that in the fast food industry- the pizza market, companies need to be increasingly careful with their marketing activities, as standardization could not bring long-term benefits for the company in an international boundary. This is affected by the fact that cultural differences play a significant role on the success of a product in an international country. Looking at the analysis in the report advertising has been greatly affected by subtle differences as suggested by Edward Hall in this theory of High Context or Low Context cultures. The chosen companies have adapted their advertising efforts to incorporate visuals, music and information by being locally responsive. Advertising in a B2C environment must be increasingly heterogeneous as transfer of success is becomes greatly difficult. Looking at the sales promotions adopted by Dominos, Pizza Hut and Papa Johns in order to gain a short-term response in increased sales these companies have been greatly responsive to differences in cultural norms, their target markets and government regulations in dissimilar markets Pricing has also been a determinant in the success of a company in an international country. The findings suggest that pricing must be alert to accommodate national customer purchasing powers. Different stages in the evolution of the PLC in chosen countries like China, India, Mexico and USA also greatly affect the pricing of a company thereby resulting in the success or failure of a brand. Marketing activity that incorporates branding analyses the fact that with a standardized brand in international boundaries like Papa Johns gives increased brand coherence and is easily transferrable into an international markets. Pizza Hut on the other hand having created a personality with its customers could not alter its brand name and logo, as customers were not accepting of the idea. Having placed significant amounts of emphasis on the closest form of contact between customers and the company, Pizza Hut has used an innovative concept wherein a man guides customers through the Indian website meeting subtle cultural associations in terms of gestures and facial expressions. Dominos have also been innovative adapting their websites to meet the growing technologically savvy customers and have introduced new tracking techniques etc, giving customers a clear understanding of where their pizza is during the production and exactly how long it will take. Owing to these marketing activities analyzed in the report it is evidently clear that companies although focus on sales promotions being short term, in order to gain long term benefits the company must adapt itself meeting local requirements. These companies as seen also provide enough standardization so as to reap benefits from brand salience and resonance.

Causes, Diagnosis, Treatment, and Prevention of Insomnia Essay

Causes, Diagnosis, Treatment, and Prevention of Insomnia Insomnia means having trouble with the quality or quantity of sleep. It can be caused by difficulties in either falling asleep or staying asleep. Self-reported sleeping problems, hating the sleep quality and day time tiredness are the only defining characteristics of insomnia because it is such an individual experience. The concept of good sleep is different from person to person. While the average night's sleep for an adult is around seven or eight hours, some people only need four, while others like up to 10 hours or more. What seems like insomnia to one person might be considered a good sleep by another (Florence Cardinal, Your Guide to Sleep Disorders.) There are three types of insomnia: Secondary insomnia, Primary sleep disorders, and Idiopathic insomnia. Secondary insomnia is due to a range of medical and psychiatric problems and the chronic use of drugs and alcohol. Primary sleep disorders include circadian rhythm disorders, central sleep apnoea-insomnia syndrome, inadequate sleep syndromes and periodic limb movement or restless legs syndromes. Idiopathic insomnia is sleeplessness without a known cause, formerly called childhood onset insomnia. (Defined by Florence Cardinal, Your Guide to Sleep Disorders.) In this paper I will try to go over all the causes, diagnosis, treatment, and prevention of insomnia. I will go over all the many people who suffer from insomnia and why? The topic is something I understand somewhat because I have suffered from this sense the year 2000. Hopefully I will be able to inform and maybe understand this problem better with this research. A reaction to change or stress is one of the most common causes of short term insomnia which includes an acute illness, injury or surgery, the loss of a loved one, job loss, extremes in the weather, an exam, traveling, or trouble at work the list can go on and on. In most cases, normal sleep almost always returns when the condition resolves, the individual recovers from the event, or the person becomes accustomed to the new situation (Lamberg &Smolensky, 2000.) Then there is real insomnia or what doctors call Psycho physiologic insomnia which could happen if the short term insomnia is not solved. In many cases, it is unclear if chronic insomnia is a symptom of some physical or psychological condition or if it is a primary diso... ...tressed out that we can't sleep at night. Insomnia can affect a person really fast and it's hard to get rid of this disorder without a lot of effort. If we follow the advice of the doctor’s and begin to live a structured life all could be well. Bibliography A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission. Retrieved March 19, 2005 from http://www.urac.org/ Cardinal,F.(2004). You’re Guide to Sleep Disorders. Retrieved March 19, 2005 from http://www.adam.about.com/ (2003) National Center on Sleep Disorders Research. Retrieved March 19, 2005 from http://www.medceu.com/course-no-test.cfm?CID=1109/ Smolensky, M., & Lamberg L. (2000) The Body Clock Guide to Better Health. Retrieved March 19, 2005 from http://www.aamcc.org/body_clock.htm (2004) University of Maryland Medical Centers Insomnia Research. Retrieved March 21,2005 from http://www.umm.edu/ President and Fellows of Harvard College (1998 Dec.1) Insomnia: Get a Good Night Sleep. Retrieved March 21, 2005 from MEDSYS database. Heilman, E. (2000). Rest for the Weary: Words from an Insomnia Expert. Retrieved March 21, 2005 from http://www.healthysleeping.com/

Facts about Ecstasy :: essays research papers

  Ã‚  Ã‚  Ã‚  Ã‚  Ecstasy, or MDMA, has become a major drug problem in the last few years. Although it is widely used, it has been proven to be dangerous. Ecstasy is a designer drug, which means it is synthetically made by street chemists. These people are not usually certified chemists and are in it for the money. This makes taking E even more dangerous. Ecstasy effects are very similar to Amphetamines and speed. Although the chemical structure is not similar to these other drugs, the effect on the body is the same. This is an informational article and in no way endorses the use of ecstasy, since it is a dangerous and illegal drug. NAMES   Ã‚  Ã‚  Ã‚  Ã‚  Ecstasy, since it is highly illegal, naturally has many names to cover its true identity. Ecstasy is also known as MDMA, pills, Adam and eve, X, E, Ecstacy, XTC, or Adam. Some fake-ecstasy drugs can be bought over the counter, such as Cloud 9, or The Pill. These are herbal fakes, and are considered by experts to not be anything like ecstasy in its true form. They may say they are ecstasy, but they really aren’t.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   DOSAGE   Ã‚  Ã‚  Ã‚  Ã‚  A average person must take 100-159 milligrams orally to feel the full effects of this drug. The drug works quickly, and effects will be noticed about forty-five minutes later. As with other drugs, if it is smoked, snorted, or injected, it will work quicker. The physical effects generally last about eight hours. The mental effects can last much longer, with them trailing off around one or two days.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   MENTAL EFFECTS   Ã‚  Ã‚  Ã‚  Ã‚  The mental effects of ecstasy are sometimes hard to describe since they are mental feelings. Scientists have classified the major mental effects of ecstasy. Entactogenesis is the first major effect of ecstasy when people feel that everything is right and good with the world. They also find interest in common everyday objects. They just have a general happy feeling. Empathogenesis is the next major effect of ecstasy; it is seems to create a feeling of closeness to others and a breakdown of communication barriers. So it seems to make you be much for open with people than before. This effect probably helped ecstasy earn its name of the Love Drug.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  PHYSICAL EFFECTS   Ã‚  Ã‚  Ã‚  Ã‚  MDMA can create any number of physical effects such as dizziness, accelerated heartbeat, sweating, insomnia, incessant talking, euphoria are all experienced. Many users report a loss of judgment, which can threaten physical health. Almost every user of ecstasy has major loss of body fluid through sweating.

Frosts Desert Places Essay -- Robert Frost Poem Poetry essays researc

Desert Places   Ã‚  Ã‚  Ã‚  Ã‚  In the poem Desert Places by Robert Frost, the author describes the scenery in which he came across with. It was on a winter day, and the day was turning into a night. As he went across a field, he saw that the ground was almost all covered in snow. But then he noticed a few weeds and stubble on the ground.   Ã‚  Ã‚  Ã‚  Ã‚  On the first line, Frost talks about how the night falling fast. This is referring to how fast Frost felt concerning time, which went by fast in real life. At the end of the line, Frost added two simple words which seems to add a sense of desperation, or even a sense of hopelessness, to the whole idea of time going by fast. The words â€Å"oh, fast† seem to show that although Frost did not like it, but there was nothing he could do or change about it. Time will ...

Salbutamol Resistance

The maximum effect can take place within five to fifteen minutes. The other routes are orally (via tablets) and intravenously. Salomon has a number of medical uses, but It is mainly used to treat asthma and exercise Induced bronchus's. Treatment of chronic obstructive pulmonary disease Is another key use of this drug (diseases In this category Include chronic bronchitis and emphysema). Other less widely applied uses is in treatment of premature labor in obstetrics since the drug can also relax uterine smooth muscles intravenous administration) and in the treatment of cystic fibrosis in combination with other drugs (3).Despite ten Tact Tanat tens Aragua NAS Eden Invaluable In ten treatment AT serious medical conditions like asthma, there is still a serious pitfall in the long-term use of the drug since most people who have been on it for a long duration tend to the develop some form of drug resistance/tolerance to the drug. This results in a slower and less dynamic effect of the drug on patients who have been using it chronically. Therefore, directly translating to the need to adjust dose and frequency of the drug administration, this can become quite a burden to everyone involved.Down regulation of the ;2-receptors and a reduction of their sensitivity (desensitizing) causes this resistance (4). The drug has an intricate mode of action that involves a number of pathways at microscopic cell level. Initially, it acts by binding on beta adrenaline receptors (4). The receptor is coupled to a stimulatory guanine nucleotide-binding protein (as – protein) and usually fluctuates between different conformations in the inactive state (5). Once the agonies (Salomon) binds to the receptor, it stabilizes one of the information leading to the activation of the G-protein.The G-protein is a transmigrate signal transducer that has alpha and beta-gamma subunits (6). After activation of the protein the alpha subunit dissociates, resulting in a form that stimulates activity of the enzyme densely cycles (7). This enzyme now increases the production of cyclic adenosine Mephistopheles (CAMP) in the cell. It does this by transforming adenosine troposphere (TAP) into CAMP through depopulation's and structure shifting (8). Increased levels of CAMP results in activation of CAMP- dependent protein kinas A.Protein kingies are enzymes that modify proteins by adding to them a phosphate group(usually derived from TAP). This phosphorescently leads to a functional change in the targeted protein either by altering the enzyme activity, its intracellular location or its interaction with other proteins (9). Protein kinas A is a CAMP dependent kinas and in the activated form, it works in two ways (all of which leads to relaxation of a smooth muscle); first, it decreases the acting- myosin interactions by phosphorescently the myosin light chain (10). Secondly, it lowers intracellular calcium concentration in the smooth muscle cells.This reduction comes about via two well researched and understood mechanisms. The first mechanism involves the regulation of influx and efflux of calcium through the calcium channels in the sarcoma (which is the cell wall). Protein kinas A causes the channels to increase the efflux of calcium from the cell and decreases influx (11). The second mechanism involves the ceroplastic reticulum which is the chief store of calcium in the cell. The kinas stimulates uptake of calcium into the store, therefore, reducing its overall concentration in the cytoplasm (12).The effect of these woo mechanisms (low calcium) leads to smooth muscle relaxation. Lastly, research shows that raised levels of CAMP causes a cessation of the release of mediators of inflammation from mast cells in the respiratory tract (13). All of these elaborate actions give Salomon its potency in dilating constricted airways and reducing obstruction secondary to inflammatory processes. But prolonged use and exposure to this drug leads to development of a resistance to it. Many schools of thought have come up with possible explanations as to now tens napes rater years AT Intense research.However, ten most accepted explanation is down regulation of the ;2-receptors and desensitizing of the same (14). It is now universally accepted that a cell's surface expression of this receptor and its coupling to signaling pathways inside the cell shows a negative feedback loop that works to reduce the cell responsiveness to prolonged occupation of the receptor by agonies lagan's. When an agonies attaches to the receptor, the stabilization involves phosphorescently (15). This usually interferes with how the receptor couples with the Gas-protein; therefore, limiting its function in what is commonly referred to as desensitizing.Desensitizing thus leads to reduction in the activation of intracellular signaling pathways secondary to prolonged receptor stimulation (16). This mechanism of uncoupling is rapid and reversible in nature, usually seen after short-term exposure. Phosphorescently of the receptor usually happens due to protein kinas A dependent pathways or by activation of G-protein receptor kingies named beta -ARKS (17). Tissues of different types show different degrees of this uncoupling when exposed to stimulatory lagan's, and this can be due to the differences in activity of the above mentioned phosphorescently mechanism.Apart from desensitizing another key process leading to Salomon resistance is the receptor down regulation. When ;2-receptors stimulation occurs for prolonged duration, they show a negative feedback mechanism that reduces their quantity of expression on the cell surface (18). The mechanism behind this is not particularly clear, but it is strongly believed to be due to receptor trafficking to lissome for destruction. Research has shown that chronic exposure to Salomon does not only lead to uncoupling but also receptor initialization from the cell surface.Initialization occurs through the process indications, whic h happens via Claritin coated pit endoscope pathway that works by forming buds from the cell membrane (19). When this process begins, Claritin (which is a small intracellular protein) begins to arrange on the inner surface of the cell's plasma membrane below the soon to be internalized receptor. The linear ends then start coming together to form a circular Claritin coated pit that has now engulfed a part of the plasma membrane, the receptor and some extracurricular fluid (20).The pit buds off into the cell and the ends of the plasma membrane come together to correct the deficit left on the surface. This pit is now referred to as a vesicle, and it traffics contents to a cell organelle known as a lissome (21). This organelle has an acidic environment and a number of enzymes that breakdown fats, proteins and carbohydrates. The vesicle fusses with the organelle's membrane and regurgitates its contents leaving the Claritin molecules on the surface (22). The receptor and other contents ar e consequently degraded. This is not the only aspect of down regulation that plays a part in reducing receptor expression.Research has shown that ;2-receptor Mrs. levels significantly reduce in the nucleus when levels of protein kinas A become elevated for long durations (days to months). Clinical features Clinical features of Salomon resistance occur when patients are intolerant to the drug therapy. Recovery, after therapy, is prolonged or absent even after maximum amelioration AT receive dose. I en most gallants clinical Torture appears in the deterioration of asthma and the subsequent exacerbation of the symptoms. Drug resistant asthma presents with (23); Worsening dyspepsia. Continuous wheezing and breathlessness. Chest tightness.These patients have developed tolerance to Salomon, therefore, are resistant to the therapy. With subsequent increase in the dose therapy which is not effective, patients with theoretically hyper-responsiveness with or without exposure to allergens and with the resulting inflammatory changes and bronchi-constriction, asthma worsens. The most severe clinical feature can present like status asthmatics or acute severe asthma. This present as episodes of severe asthma, failing to respond to usual effective doses of Salomon (24). There is progressive respiratory failure even within the course of therapy.This episode can progress to fatal asthma. Patients present with; Significant wheezing and dyspepsia. Severe respiratory distress. Hyperventilation and subsequent respiratory leukemia. Features of metabolic acidosis due to anaerobic respiration and elevated levels of lactate from the respiratory muscles (25). Severe asthma will occur with increasing degree of hyper-reactivity due to intolerance to drug therapy: ineffective relief and loss of bronchitis tone. Clinical feature can also occur as a result of high drug dosage. Resistance causes a patient who is in respiratory distress to use increasing and more frequent doses of albums.High doses produce toxicities which can present with systemic features (26). In the respiratory system; there can be hyperemia. Salomon is a psychosomatic agent (beta 2 agonies) the vacillators effect of beta 2 Zionists increases perfusion of poorly ventilated lung units, transiently decreasing arterial oxygen tension (27). Significance of this effect depends on initial partial pressure of oxygen of the patient. Hyperemia will present clinically as occasions, respiratory distress, and tachyons. There can be paradoxical bronchus's due to the Atonally antagonism to Transcendentalist erect AT SalomonI en spasms, AT the smooth muscles lining the bronchi, are due to psychosomatic action of Salomon and adrenaline stimulation. In the cardiovascular system, the psychosomatic action of Salomon can cause toxicity which might result in cardiac arrhythmias, arterial fibrillation, supercritical tachycardia and extra systole (29). There can be an occurrence of coronary insufficiency due to hyperemia, atheistically and resulting tachycardia, peripheral bastardization with a compensatory small increase in heart rate, hypertension and palpitation. In the endocrine and metabolic system, there can be hypoglycemia.Salomon may stimulate sodium and potassium Tapes which causes redistribution of electrolytes (30). Hyperglycemia in a diabetic patient; Salomon stimulates the beta 2 transporters which stimulate hepatic glycogen breakdown for pancreatic release of clangor which increase plasma glucose. In the central nervous system, overdose of Salomon therapy intolerance can produce CONS symptoms such as insomnia, weakness, dizziness, nervousness, tremors, transient muscle cramps and headache. Rarely reported effects include drowsiness, irritability, chest discomfort and difficulty in instruction (31).Diagnosis Diagnosis of Salomon resistance follows the clinical guidelines of a full comprehensive history of the patient, physical exam, and investigation to confirm the patient's tolerance to drugs. In taking the history certain question might lead to the discovery that a patient previously on Salomon therapy is unresponsive to the drug. When doing a physical exam, clinician should check out for general observation such as respiratory distress and occasions. In doing a systemic exam, focusing on the respiratory system may bring out worsening respiratory function.Clinician may find wheezing with other signs indicative of exacerbated asthma. Investigation Investigative studies are confirmatory and supportive to the diagnosis. The base lines include; Full blood count. Urea electrolyte count. Liver function tests. Random blood sugar if suspecting diabetes. I en consoler long toner tests In prospector s o mol toxicity al u TA Pulmonary function tests Serum blood gas analysis with pH profile Cardiograms to check arrhythmias Gene typing; the cornerstone of Salomon resistance detection is gene typing. Experimental studies have shown that tolerance in asthma is in the polymorphi sm of he DRAB gene.Analysis show that tolerance is in the glycogen allele at position 16 and 21 at the beta receptor gene. Gene typing for polymorphism can aid in identifying patients with drug resistant asthma (32). Management Management can be categorized as supportive, specific, preventive and rehabilitative. Supportive management include; Outpatient monitoring if not severe Admission to a hospital if severe. Severe asthma necessitates immediate admission as it can be fatal. Oxygen therapy. Intubations and mechanical ventilation if severe. Use of parental corticosteroids which are anti-inflammatory.Fluid and electrolyte resuscitation in the case of hypoglycemia. Frequent monitoring of patients to the drug. Specific management is both surgical and medical. Surgical management, research is still underway and ongoing. Medical management includes the use of a second-line therapy like monopolies, astatine and antihistamines. There is also use of cardiac-selective beta adrenaline block ing agents and corticosteroids in Salomon toxicity. Other drugs can be used depending on symptom's of resistance, for example; interventions, insulin and any other depending on the symptoms of the patient.Surgical intervention for example attempting bronchial thermoplastic. This is a bronchitis procedure in which delivered thermal energy to airways; it reduces airway smooth muscle hyper responsiveness. It has been also shown to be beneficial in treatment of severe asthma where continuous therapy has failed. Preventive management Includes gene typing early enough to Isolate patients wilt Salomon resistance by checking the beta AR gene. The other way is to prevent high-drug toxicity. Rehabilitative management of any complication that might occur is essential.

Characters in Great Expectations Essay

In this first extract there are many hidden connections between the characters and the settings. The first connection is when Pip the narrator describes the graveyard. He describes it as a â€Å"bleak place overgrown with nettles†. The word bleak alone reflects many characters feelings. The word bleak may perhaps represent how Pip feels about the place he has to mourn for his family and how he is in disbelief that a place of death and rebirth could be so uncared for. I think this uncaring for the graveyard is a strong reflection of Pips character, as he himself is uncared for. It could also symbolize Pip’s life so far as being miserable and empty and never having anything to look forward to. However I think the main thing the word bleak is trying to signify is the â€Å"fearful man† Magwitch. This convict’s life will be bleak even he does not go back to prison. This is because he has no option, no friends or family and he is alone in the world. Pip the narrator describes the area surrounding the churchyard as a â€Å"dark flat wilderness†. This quote is another representation of Pip’s life . The word â€Å"dark† indicates Pip’s past and how it is dark and cloudy as he does not know anything about it. The word â€Å"flat† signifies Pip’s life at the moment as being straight forward and plain with nothing changing and the word wilderness representing Magwitch and how Magwitch is going to change Pip’s future from flat and straight forward to wild andchanging. The quote also may represent Pip’s existence as he has always been alone, never knowing any of his family apart from his sister. Furthermore the fact that Pip is alone in this harsh abandoned environment makes the area more scary and dangerous. So when Dickens refers to Pip as a â€Å"small bundle of shivers† it creates an image in the readers mind of Pip curled up all alone in this â€Å"overgrown† â€Å"wilderness† which I think increases the readers sorrow for Pip. Moreover the word â€Å"bundle† emphasises how small Pip is which may increase the readers sorrow for Pip even more. This atmosphere created by Dickens gives a good entrance for the character Magwitch. Magwitch is mirrored through the landscape and the words Dickens uses so that he is not only created through words but from the settings. The words and settings that are used to emphasise Magwitch are mainly employed to dehumanise Magwitch so that he seems more like a monster then a man. Magwitch is first introduced at the graveyard, where he scares Pip not only with his words but with his image. This is shown before Magwitch is even introduced into the play by the narrator. The narrator refers to a wind rushing from a â€Å"savage lair†. I think this wind from the savage lair is Magwitch and how he is being blown ever closer to Pip. I also think that the word â€Å"savage† could be referring to the prison Magwitch was in. As it shows the fact that a prison is a place for savages. This idea increases the reader’s view of Magwitch making him more of a beast then a man. The assumption that Magwicth is a beast is also supported by the fact that Dickens followed â€Å"savage† with the word â€Å"lair† the word lair is mainly used to describe an animal’s home which enhances the idea of Magwitch being an animal. I think Dickens does this to dehumanise Magwitch further and also to create an image in the readers mind just before Magwitch is introduced into the extract. Magwitch is an escaped convict which makes his options â€Å"bleak† that’s why I think he ends up at the graveyard because if your options are â€Å"bleak† you usually only have the worst choices to choose from. The word â€Å"overgrown† suggests how Magwitch is out of control which makes him more like a wild monster. In addition the word â€Å"nettles â€Å"could be representing Magwitch being sharp, painful and dangerous. These quotes show that nature has personified Magwitch into a wild beast. When Magwitch is first described by the narrator, one of the first things that he is described as is â€Å"a man with no hat†. I think this is said because in the times of Great Expectations gentleman usually wore top hats. Dickens is trying to show that Magwitch is no gentleman. At the end of extract one Magwitch asks Pip where his village lies. This I think has a small reference to Mr and Mrs Gargery, as they both are included as the â€Å"village† that Pip points to when Magwicth threatens him in the Graveyard. The village â€Å"lay inshore among the alder trees,†. As a result of this quote we draw together the image of a peaceful village. This quote illustrates the meaning of the word â€Å"lay† as this one word indicates that the village was asleep and unaware of Magwitch’s presence. This extract shows how well the settings of Great Expectations not only contribute to the story but to the characters emotions as well. Extract two takes place in Satis House. This old outdated building creates the feelings and atmosphere for this extract. The extract begins with Pip describing the room he is in and giving us an image of what it looks like. Pip then meets Miss Havisham and refers to her as the â€Å"strangest† thing he has ever seen. Miss Havisham talks to Pip about herself and gives him a brief outline of her past telling Pip how she has never seen the sun since she was left at the alter by her husband. After this Pip meets Miss Havisham’s daughter Estella. Estella and Pip play the card game â€Å"beggar† while they are playing. Estella insults Pip by saying that his hands are all coarse. The extract ends with Pip leaving Satis house and then releasing his hatred towards Estella by kicking a wall while he cries. Extract two on a whole fits into Great Expectations as the Part of the novel that misleads the reader so that the reader thinks that Miss Havisham is the mysterious benefactor who gives Pip money so that he can move to London to become a gentleman. I think Dickens does this to try and remove the character Magwitch from the readers mind so that the reader will not even in the slightest think that Magwitch is Pip’s benefactor and that Magwitch role in Great Expectations has ended. However even though Charles Dickens does this, he still leaves a presence of Magwitch in the novel. This presence comes from the character Estella. Estella just like Magwitch is sprung onto Pip. Magwitch is sprung onto Pip in the literal sense as he just jumps out at Pip scaring him. In comparison Estella is released onto Pip in another way. Pip who finds Estella â€Å"pretty† is just sprung by the insults and â€Å"distain† she shows towards him. The settings in extract two mainly represent the character Miss Havisham showing why she lives her life the way she does and exposing her past to the reader. The character Miss Havisham is not exactly a very believable character as no one in their right mind would live there life the way she does just because they were left at the alter. However even though she is not a very realistic creation from Charles Dickens she is certainly one of the most interesting characters of the novel. Miss Havisham’s whole life is defined by the single catastrophic event of her being left at the alter. From that moment forth, Miss Havisham is determined never to move beyond that day. She stops all the clocks in Satis House at twenty minutes to nine, the moment when she first learned that her future husband was gone. Extract two begins with Pip the narrator describing what the room Pip is in looks like. The room is described as a â€Å"pretty large† room well lit with â€Å"wax candles†. It is also said that the room does not even have a â€Å"glimpse of sunlight. † These quotes create the atmosphere of the room which make it seem mysterious and depressing. In addition these quotes reveal a lot about the character Miss Havisham. The quote a â€Å"glimpse of sunlight† is not only saying that room does not even have a glimpse of sunlight it is also reflecting things about Miss Havisham showing how she herself is the one without a glimpse of sunlight. The fact that Miss Havisham is keeping herself from the sunlight (the sunlight I believe could represent the public) suggests that she is trying to keep her past from the sunlight by staying in the dark. Sunlight is often associated with bliss and happiness. As there is no sunlight in the room it emphasises her life as being unhappy.